Prostate Cancer Research - The Promise Of Pomegranates

Pomegranates have long been used in traditional folk remedies to treat sore throats, inflammation, and rheumatism. And recent scientific research has suggested they are also potentially effective in both preventing and treating prostate cancer.

One study, conducted on human prostate cancer cells in lab dishes, at the University of Wisconsin, found that there were dose dependant improvements. Another study at the same facility injected mice with human prostate cancer cells. These mice developed malignancies. Some mice were fed plain water, whilst two other groups of mice were given water mixed with different concentrations of pomegranate extract.

Those mice that had water only had tumors that grew much faster than the pomegranate and water groups. The quantities given to the mice were comparable to that which people might get if they drank pomegranate juice on a daily basis. And whilst pomegranate juice hasn't been tested on humans with prostate cancer yet, the results are very good.

The study did not indicate what aspects of pomegranate juice were responsible for slowing down prostate tumour growth. But the scientists involved did mention the antioxidant polyphenolic compounds, which are more effective than green tea and red wine.

Pomegranate extract not only inhibited the growth of cancer cells, it also worked by another means - apoptosis.

Apoptosis refers to a way that cells can die. Cancer growths are characterized by an uncontrolled growth of cells that do not follow the normal processes of cellular differentiation of regular, healthy cells. Cellular differentiation means that the characteristics of a cell change and get the functions that a mature, healthy cell would. For example, liver cells have specialized liver functions, as do prostate, breast, kidney, and all other types of cells. This is normal and healthy.

In tumour growths, although some cells fully differentiate, many only differentiate partially, and some not at all. And the tumors which have more undifferentiated cells grow faster. So, inducing cellular differentiation is one approach to cancer treatment. The other two ways that doctors and researchers try to treat cancer is by causing the death of cancerous cells. They do this through apoptosis, mentioned above, and necrosis.

In apoptosis, cell death is programmed into the cell when it is 'born'. So the cell dies in a more natural way that is less destructive on its environment. By this I mean it doesn't cause inflammation and the damage associated with it to neighboring cells that may be healthy. Cells die either when they reach cellular old age or when their death benefits the body as a whole. Necrosis, on the other hand, does cause inflammation.

Generally, prostate cancer grows very slowly, although it is unpredictable and can grow quickly and spread.

References:
1. John Boik, Cancer and Natural Medicine (Oregon Medical Press, 1996)
2. Australian Healthy Food, March, 2006
3. www.nutraingredients-usa.com/news/ng.asp?id=62811
4. www.nutraingredientsusa.com/news/ng.asp?id=62811

If you're interested in a good health prostate supplement, click here, and check out the prostate health tips. Maca root is another great supplement for regulating and normalizing hormones, for both men and women. Rebecca Prescott runs this website that provides researched information on vitamins and supplements.

Drinking Milk and Sunshine Exposure Can Limit the Prostate Cancer

The spread of prostate cancer is caused by the over normal activity of two specific enzymes, proteases called cathepsin and matrix metalloproteinase.

A recent study concluded that Vitamin D can reduce the activity of these enzymes, mainly by increasing the level of counterpart enzymes that inhibit matrix metalloproteinase and cathepsin. This process has two consequences on prostate cancer. On one hand, it creates a limitation in power of prostate cancer cells to invade healthy cells and, on the other hand, it has a positive effect on plasminogen activators, which also are important in uncontrolled prostate cancer spreading mechanism.

For a moment it is unclear whether there are other vitamins and medicines that could increase the anti cancerous effects of Vitamin D. The scientists are now investigating if Vitamin E could be a positive support without increasing the toxic level.

Patients must know that a high dose of Vitamin D has a strong side effect causing kidney problems due of increasing blood calcium levels. For this reason, it should not be taken without medical prescription and a special monitoring of side effects by a professional health care.

Excepting vitamin pills, the best ways to get Vitamin D into the body are to drink milk and to expose the body to the modest sun (sunshine preferable).

Valerian D is a freelance writer interested in health issues affecting men such as prostate cancer

What a Man Must Know About Prostate Cancer!

1 Testosterone and its active metabolite.

Dihydro-testosterone are essential for prostate cancer to develop, but does not actually cause prostate cancer. Men who are castrated at a young age do not develop prostate cancer.

2 Prevalence of prostate cancer

One in ten men will develop clinically significant prostate cancer in their lifetime. It is the most commonly diagnosed cancer in American males with 250 000 new cases reported annually. Prostate cancer is second only to lung cancer as a cause of cancer death in both the USA and the UK. Prostate cancer is rare among Orientals. It is more common in black than white Americans. The disease appears to present at a younger age and behave more aggressively in American blacks. Prostate cancer is common in South Africa and probably underreported as a cause of death. The exact incidence in South Africa is not known as no large-scale epidemiological studies have been performed. It is uncertain whether prostate cancer is more common in South African blacks as compared to whites. In very old men prostate cancer is not always clinically significant. Autopsy data indicate a 70% incidence of prostate cancer in 80 year old men. The majority of these men died with rather than from prostate cancer.

3 Causes of prostate cancer

There is no single cause of prostate cancer. The cancer originates in the epithelial cells of the glandular elements of the prostate. As with most cancers defects in the DNA of the cell are central to the development of prostate cancer. Multiple DNA defects are required for cancer to develop. This multi-step process takes place over time. Some defects can be inherited, while others are acquired during the patient's lifetime. Prostate cancer is exceedingly rare before the age of 40, but 1 in 8 men between the ages of 60 and 80 years suffer from the disease. 9% of all prostate cancers are caused by a genetic susceptibility, probably inherited via chromosome 1. These genetically related cancers tend to present at a relatively younger age.

4 What is prostatitis?

Prostatitis means ?inflammation of the prostate?, and is one of the most common reasons men visiting the doctor in the western world. It is most common in men over the age of 30, and particularly in men over the age of 60. While prostatitis is treatable, diagnosis can be lengthy and not all treatments are successful. This is partly because the various causes of prostatitis are not fully understood. There are three main types of prostatitis:

? Acute prostatitis, which develops suddenly and may not be permanent.
? Non-bacterial prostatitis, which may develop suddenly or follow a slower or variable course. It is now more commonly called chronic male pelvic pain syndrome because it cannot be proved to be ?non-bacterial?, though a bacterial cause cannot be identified.
? Chronic (bacterial) prostatitis, which develops gradually and may only have subtle symptoms, though it often continues for a prolonged period.
? asymptomatic inflammatory prostatitis - which has no symptoms at all but results in an inflamed prostate, is sometimes mentioned. It has been discovered when biopsies are conducted on the prostate to rule out cancer, and no cancer is found. This is a histological and not a clinical diagnosis. Prostatitis is often reported on the histological analysis of TURP specimens when the prostate resection was performed for symptoms of BPH. If the patient is asymptomatic this histological finding does not warrant any treatment.

With our next information - we will inform you about the ?Symptoms of prostate cancer? - so you should have a look on this site in the next 2 weeks! If you have any question send us your e-mail.

Fritz Frei make it easy to check out the important details about the diagnoses and test's of the Male - Breast-Cancer. To receive more information's about all cancer -questions - Links and last research NEW's - visit the http://www.cancer-info.info

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What Is Prostate Cancer - Understanding It From All Aspects

What is prostate cancer? This is a question many people have asked themselves after they, like millions of others, have been diagnosed by their doctors with the problem. An answer to the question of "What is prostate cancer" isn't an easy one either.

Defining the Disease

The first step to finding the answer to this fairly common question is to understand the basic nature of the disease. Prostate cancer is a growth of abnormal cells in the prostate gland. It can be caused by a number of factors, and if it is treated immediately, it is unlikely to be fatal.

Who Gets Prostate Cancer?

This question is a bit tougher to answer than "What is prostate cancer." Scientists are desperately trying to find a connection among victims of this horrible form of cancer so as to better understand the course of the disease itself. In general, prostate cancer victims are thirty percent of all male cancer cases in the United States. Black men tend to suffer from the problem more than white men, and the older you get, the higher your risk factors are for prostate cancer. The country at highest risk for prostate cancer is Scandinavia, and men in China are at the lowest risk in the world for developing the disease.

When Should I Start Checking?

Doctors suggest that only nine percent of men in their twenties develop prostate cancer, but, interestingly enough, many men who die of other, varied causes, show signs of prostate cancer in a posthumous examination environment. Because it can be so hard to spot, most doctors recommend that men start checking for this deadly killer by the time they reach age forty. Many suggest a prostate exam is necessary on a yearly basis.

Understanding the answer to the question "What is prostate cancer," is truly necessary for the complete eradication of this horrible condition.

Dean Iggo is the webmaster of www.prostatehealthadvice.com which provides the causes of prostate cancer and treatments of everything from an enlarged prostate to prostate cancer

Living With Prostate Cancer

The baby boomer population bubble has now reached 60 years old. This means that many of us are going to need to face illness and diseases that come with surviving six decades. Prostate cancer is one such disease that is expected to grow in number over the next few decades.

Statistically 180,000 new prostate cancer cases are being diagnosed in the United States every year with about 32,000 men dying from this disease annually. Although these are the statistics that are used, the fact is that many of these men will will die and not from the actual prostate cancer, but from allowing the cancerous condition to grow until it is unmanageable. This is due to the fact that prostate cancer can metastasize or move from the prostate area and infect organs, bones and lymph nodes.

This should cause every man to pause and realize that prostate cancer is a serious disease that if given the chance will kill you. It is now the second leading cause of cancer deaths among men in the United States after lung cancer. In Canada about 17,000 males are diagnosed with prostate cancer each year and about 4,200 die each year from the disease.

The sad fact is that many of these deaths are avoidable. As with many cancerous diseases, early detection is the key to effective treatment and even cure. Prostate cancer is diagnosed based upon how advanced the malignant tumor has grown. In the early stages, we have maximum flexibility in treatment options and can both manage and in many times cure this potentially deadly disease.

Diagnosis usually start with a medical history as studies have shown that heredity may be a factor with prostate cancer. Next, a DRE or digital rectal exam is done. This is a quick and simple exam where the doctor feels your prostate for any abnormal bumps, size difference or texture. In addition to a DRE, the doctor may suggest a Prostate-Specific Antigen (PSA) blood Test. This blood test looks for abnormal markers that may indicate the presence of a developing cancerous situation.

There's growing evidence to suggest that a diet very rich in vitamins and nutrients can also help maintain our body's ability to ward off many serious diseases. Although the definitely not a cure for prostate cancer, the use of natural remedies to strengthen your body's immune system can only help to keep you healthy. There's no question that a low-fat diet along with appropriate vitamins and minerals can help keep you healthier and make you better able to fight off disease.

Several studies have suggested that men who had a diet rich in selenium and vitamin E. had fewer cases of prostate cancer. The kinds of foods that contain selenium include meat, grains, seafood, and some kinds of nuts. It's critical that you meet with your doctor before making any radical changes to your diet as other problems may arise. There's also some evidence to suggest that the nutrient lycopene found in tomato based products such as ketchup can provide some protection against contracting prostate cancer.

According to a study in the British Journal of Urology International, men that have been diagnosed with prostate cancer who take supplemental lycopene (is found in very high amounts in tomatoes) and still get their testicles surgically removed are likely to experience less bone pain, less disease and stand more chances of living longer than those who have only had surgical removal of their testicles.

In the end, a partnership with your medical doctor is the best way to remain healthier longer. By taking some responsibility for your health, changes in your lifestyle are much easier to make.


Abigail Franks writes on a variety of subjects which include family, health, and home. For more info on Living with prostate cancer visit the sites at http://www.prostate-cancer-treatment-expert.com/more_articles/prostate-cancer-support.php and http://www.prostate-cancer-treatment-expert.com

Lycopene Effective with Prostate Cancer Treatment

Men with prostate cancer who take supplemental lycopene in addition to surgical removal of the testicles may experience less active disease, less bone pain, and live longer than those who only have surgical removal of the testicles, according to a new study in British Journal of Urology International (2003;92:375–8). This is exciting news for millions of men who have to undergo aggressive treatment for advanced prostate cancer.

Prostate cancer is the most common cancer found in men over the age of 50 years, with more than 200,000 new cases each year in the United States. The cause of prostate cancer, like many other cancers, is unknown; however, some studies suggest alterations in testosterone metabolism may play a role in its development. Prostate cancer is generally slow growing and may not cause any symptoms until late in the disease. Symptoms may include frequent or painful urination, dribbling after urination, sensation of incomplete emptying of the bladder, or blood in the urine. The symptoms of prostate cancer are similar to those of a non-cancerous condition called benign prostatic hyperplasia (BPH), so men experiencing these symptoms should consult their physician for an accurate diagnosis.

In the new study, 54 men with advanced prostate cancer were randomly assigned to have surgical removal of the testicles (orchidectomy) alone or orchidectomy plus oral supplementation with 4 mg of lycopene a day. Measurements of PSA (a blood marker of prostate cancer activity), bone scans, and urinary flow were taken initially and every three months for two years. Men receiving lycopene started on the day of their surgery.

After six months, PSA had significantly decreased in both groups, indicating a reduction in prostate cancer activity. However, PSA levels in those receiving lycopene were more than 65% lower than in those who did not receive lycopene. After two years, PSA levels in the lycopene treatment group had fallen into the normal range, while those who only underwent surgery still had PSA levels more than twice the upper limit of normal. Urinary symptoms significantly improved in both groups, but better improvement was again observed in the lycopene group. The lycopene group also experienced less bone pain.

The survival rates after two years in the lycopene-plus-surgery group and surgery-only groups were 87% and 78%, respectively, a statistically significant difference. No adverse side effects were observed in men taking lycopene.LycopeneLycopene is one of a group of compounds called carotenoids. It is found in high amounts in tomatoes.

The findings of this study corroborate the findings of other similar studies examining the effectiveness of lycopene in the treatment of prostate cancer. However, the amount used in the current study (4 mg per day) was substantially less than the amounts used in other studies (30 mg per day). It may also help stimulate the immune system and has been shown to cause cancer cells to die on their own. Although more research is needed to clarify what amount of lycopene is most effective, men with prostate cancer may benefit from taking daily lycopene supplements. Eating one moderately sized tomato a day also provides approximately 4 mg of lycopene. Other tomato products, such as an 8-ounce portion of tomato juice or tomato paste may provide up to 25 mg of lycopene.

Darin Ingels, ND, MT (ASCP), received his bachelor's degree from Purdue University and his Doctorate of Naturopathic Medicine from Bastyr University in Kenmore, WA. Dr. Ingels is the author of The Natural Pharmacist: Lowering Cholesterol (Prima, 1999) and Natural Treatments for High Cholesterol (Prima, 2000). He currently is in private practice at New England Family Health Associates located in Southport, CT, where he specializes in environmental medicine and allergies. Dr. Ingels is a regular contributor to Vitamin Herb University.marketing@webadvantage.net